LGFUS Public Data

Cancer-associated regulation of alternative splicing

Nat Struct Mol Biol. 2009 Jun;16(6):670-6

Links in this section allow the user to interactively view the data described in Venables et al. In particular it contains
  • Splicing data for all the simple alternative splicing events in the RefSeq database (annotation build 36.2) in breast and ovarian cancer not included in our previous studies of 600 genes in breast and ovary (subsections 1 to 6)
  • Splicing data for potential Fox2 knockdown targets in cell lines and for validated targets in ovarian and breast cancer (subsections 7 and 8)
  • Cartoon representation of all the splice events analyzed mapped to their corresponding encoded proteins primary structures (subsection 9)
Most pages contain links labelled "help" for explanations of the features (data and links) found therein. For example sections (2-8) ultimately link to raw electropherogram data showing expected peak sizes below, found peak sizes and molarities on top and standard markers at 70 and 7000 base pairs etc. but for more in-depth explanation when viewing the raw data traces click on the appropriately positioned help link.
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High-Throughput Quantification of Splicing Isoforms

RNA. 2010 Feb;16(2):442-9
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Identification of alternative splicing markers for breast cancer

Cancer Research. 2008 Nov 15; 68(22)

Links in this section allow the user to interactively view all the data described in Venables et al., 2008. The screen for breast cancer markers was conducted in three stages:
  1. Alternative splicing events in 600 cancer associated genes were examined in two normal breast and two cancerous breast pools, click on "Breast Discovery Screen" to view this,
  2. Promising alternative splicing events were assayed in 21 normal and 26 cancerous samples, click on "Breast Validation Screen" to view this,
  3. The markers that distinguished normal from cancerous breast were assayed in a further set of assorted breast samples, click on "breast blind set" to view this.
Most pages contain links labelled "help" for explanations of the features (data and links) found therein.
configure Open section (4 subsections)

Multiple alternative splicing markers for ovarian cancer

Cancer Research.2008 Feb;68(3):657-63.

Below is a link to the supplementary materials submitted in Klinck et al.
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Multiple and specific mRNA processing targets for the major human hnRNP proteins

Mol Cell Biol. 2008 Oct;28(19):6033-43

The link in this section allows the user to interactively view all the data described in Venables et al., 2008

Most pages contain links labelled "help" for explanations of the features (data and links) found therein.
configure [2008/03/04] Multiple and Specific mRNA Processing Targets for the Major Human hnRNP Proteins

PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa

Hum. Mol. Genet. March 5, 2011 doi:10.1093/hmg/ddr094

Links in this section allow the user to interactively view the data described in Tanackovic et al.
configure [2010/10/15] PRPF8 knockdown in human cell lines Tanackovic et al.
configure [2010/09/01] Patient screen Tanackovic et al.

SYK Alternative Splicing Regulates Mitosis and Cell Survival

Nat Struct Mol Biol. 2011 Jun;18(6):673-9

Links in this section allow the user to interactively view additional data described in Prinos et al.
configure Open section (5 subsections)

These PhD Jean-Philippe Brosseau


Tumor microenvironment associated modifications of alternative splicing

Brosseau et al. 2013
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