Cancer-associated regulation of alternative splicing

Nat Struct Mol Biol. 2009 Jun;16(6):670-6

Links in this section allow the user to interactively view the data described in Venables et al. In particular it contains
  • Splicing data for all the simple alternative splicing events in the RefSeq database (annotation build 36.2) in breast and ovarian cancer not included in our previous studies of 600 genes in breast and ovary (subsections 1 to 6)
  • Splicing data for potential Fox2 knockdown targets in cell lines and for validated targets in ovarian and breast cancer (subsections 7 and 8)
  • Cartoon representation of all the splice events analyzed mapped to their corresponding encoded proteins primary structures (subsection 9)
Most pages contain links labelled "help" for explanations of the features (data and links) found therein. For example sections (2-8) ultimately link to raw electropherogram data showing expected peak sizes below, found peak sizes and molarities on top and standard markers at 70 and 7000 base pairs etc. but for more in-depth explanation when viewing the raw data traces click on the appropriately positioned help link.

[2009/03/30] 10. Fox2 Targets

[2008/12/11] 09. Protein Maps

[2008/10/16] 01. Primer Design Maps

[2008/08/29] 08. Fox2 Knockdowns

[2008/08/27] 07. Fox2 Targets - Cancer Validations

[2008/03/31] 05. Association Screen: Ovary

[2008/03/14] 06. Association Screen: Breast

[2007/12/19] 02. Detection Screen: Breast And Ovary Combined Data

[2007/12/18] 04. Detection Screen: Breast

[2007/09/12] 03. Detection Screen: Ovary

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